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Zoloft, including the active substance sertraline, is a selective serotonin and belongs to the group of reuptake inhibitors indicated for

  • Treatment of social phobia,.
  • treatment of menstrual disorders, and
  • treatment of panic attacks in adults and children
  • treatment of all types of depression, and
  • To increase vitality, sleep, mood, and longing.

Zoloft grants for:.

  • Suppressive Disorders
  • Start dosage at 50 mg daily
  • If patient responds inadequately to 25 mg to 50 mg once a week, increase daily dose.
  • The highest dose is 200 mg daily depending on individual tolerance.
  • Obsessive-compulsive disorder

- Recommended initial dose for adults is 50 mg daily

- In children, start dosage at 25 mg for 6-12 years, then 50 mg for 13-17 years.

- If a patient has an inadequate response to 25 mg daily to 50 mg once a week, increase the dose.

- Maximum dose based on individual tolerance is 200 mg daily.

  • Menstrual disorders
  • The recommended starting dose is 50 mg daily given intermittently or continuously (round).
  • The intermittent dose should be started 14 days before the expected start of the menstrual cycle and continued throughout the macular phase of the cycle. Repeat the dosage in the following menstrual cycle.
  • The circular dose should be consumed continuously throughout the menstrual cycle.
  • If the patient is found not to be responding to the 50 mg portion, function as follows

+In the case of a patient receiving an intermittent dose, increase the dose by 50 mg in each menstrual cycle up to a maximum of 150 mg daily.

+For those on continuous doses, intensify the dose starting with 50mg daily for the first 3 days, then intensify to a ceiling of 100mg daily for each menstrual cycle and follow.

  • Depression.
  • Recommended initial dose is 25mg daily
  • Maintenance dose is 50mg to 200mg daily

Overdosage: (1)

Clinical Experience

Zoloft overdose symptoms include spontaneous changes in blood pressure, hallucinations, syncope, serotonin syndrome, man sick episodes, and seizures. Death from hyperthermia and seizures due to serotonin disturbance is unusual but feasible. Patients overdosed on a mixture of sertraline and alcoholic beverages are prone to homicidal tendencies - fatal cases have been described when Zoloft and alcohol are combined. Rare cases of SSRI-induced pancreatitis have also been reported among those who have suffered Zoloft overdoses.

Overdose Management

If a Zoloft overdose (Segraline) occurs, call your doctor, therapist, or 911 to seek emergency treatment. Or contact your local Poison Medical Center immediately.

In the event of a regulation overdose situation, emergency treatment for a Zoloft overdose may be advisable. Possible emergency measures may include

  • Activated charcoal taken by mouth to minimize secondary effects and prevent further metabolism of the drug.
  • Stomach pumping to remove the drug if Zoloft has recently been taken.
  • Consumption of sedatives such as benzodiazepines to minimize irritation and symptoms.
  • Administration of competing serotonin and/or intravenous fluid competitors to treat serotonin disturbances.

Form of the part:.

Zoloft (Segraline) tablets 25 mg, 50 mg and 100 mg.


  • Well - known hypersensitivity to amphetamine/dextphetamine

precautions and reservations:.

  • Effects on behavior and mood: do not administer to persons with previous MAN disease suppression and/or bipolar disorder.
  • Avoid consumption of MAO inhibitors such as methylene blue infusion, isocarboxazide, rasagiline, or transimpromine if consumed in the past 14 days. Stay away from MAO inhibitors for 14 days after Zoloft consumption.
  • Serotonin disturbances: see patient at points of illusions, fevers, fever, heart rate, diarrhea, vomiting, dizziness, seizures, etc.
  • Do not give Zoloft if patient is allergic to sertraline. Watch for patients who are sensitive or allergic to tartazine or aspirin.
  • Avoid giving Zoloft to patients who receive pimozide
  • Zoloft can cause heart problems, especially in patients being treated for HIV, malaria, hypertension, asthma, cancer, and psychiatric disorders.
  • Fetal and Fetal Toxicity: update pregnant mothers on the dangers of high-dose sertraline in fetal development and maturation. For nursing mothers, Zoloft may be harmful to premature infants, especially infants with reduced metabolic activity. Continued use can cause the same symptoms seen in people with neonatal abstinence.
  • Zoloft medication may cause false effects on brain scans for diseases such as Parkinson's disease.

Secondary effects:.

The most common secondary effects of Zoloft include dry mouth, decreased appetite, nausea, decreased sexual activity, insomnia, indigestion, heartburn, diarrhea, increased fatigue and drowsiness.

Rare but reported side effects include delayed male ejaculation for up to 4 hours, hallucinations, accelerated heart rate, anxiety, abnormal mouth, increased sweating, and fever.

Drug Interactions:.

  • Use with antiplatelet medications: increases risk of healing or bleeding, especially when combined with drugs such as aspirin, ibuprofen, NSAIDS, and clopidogrel. For patients preventing stroke and heart attack, give aspirin in doses as low as 81 mg to 162 mg.
  • Use in combination with MAO inhibitors: increases disclosure of serotonin neurotoxicity and cardiotoxicity disorders, which can be fatal consequences.
  • Use in combination with serotonin inducers: when combined with MDMA and various antidepressants, especially psychoactive drugs such as tryptophan, duloxetine, fluoxetine, venlafaxine, and paroxetine, increases the risk of toxicity.

Consumption in certain populations:.

Not recommended for pregnant or breastfeeding mothers

Information on patient counseling

Update patient sporadically and sporadically during treatment before starting with Zoloft.

Patients should be informed that if they are in the middle of 18-60 years and not suffering from any other disease, they may suffer from secondary effects such as nausea, sexual libido, diarrhea, insomnia, etc. if not taking other medications.

Patients should inform their therapist of any allergies that may be present, especially to medications such as talatadine, aspirin, and sertraline.

Patients should inform the therapist of any recent medications received for pimozide, Mao inhibitors or disulfiram, which are indicators of the opposite of Zoloft oral solution. Other medications that may interact with Zoloft consist of HIV antiretroviral therapy, prolysines, tricyclic antidepressants, cardiac medications, and medications that may cause drowsiness.

At the time of consumption of Zoloft, update the patient against consumption of alcoholic beverages or recreational therapy, use of illegal or psychoactive substances.

If a dosage change occurs, the patient should be able to wait a minimum of 5-7 days before making a subsequent dosage change.

Monitor patients against sudden discontinuation of Zoloft without prior medical advice or supervision to reduce the likelihood that the patient will exhibit deprivation symptoms.

Ensure that pregnant women and nursing mothers are warned about the potential risks of Zoloft to the fetus and baby.

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